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Geoscience Tags > Tag based links for Chromatid
The following links have been tagged chromatid by users just like you, because these resources are off-site we cannot guarantee the accuracy or quality of any third-party information.
- The matrix
attachment
region in the
Chinese
hamster
dihydrofolate
reductase
origin of
replication
may be
required for
local
chromatid
separation.: Proc Natl Acad
Sci U S A,
Vol. 100, No.
6. (18 March
2003), pp.
3281-3286.Cent
ered in the
Chinese
hamster
dihydrofolate
reductase
origin of
replication is
a prominent
nuclear matrix
attachment
region (MAR).
Indirect lines
of evidence
suggested that
this MAR might
be required
for origin
activation in
early S phase.
To test this
possibility,
we have
deleted the
MAR from a
Chinese
hamster ovary
variant
harboring a
single copy of
the
dihydrofolate
reductase
locus.
However, 2D
gel replicon
mapping shows
that removal
of the MAR has
no significant
effect either
on the
frequency or
timing of
initiation in
this locus.
Rather,
fluorescence
in situ
hybridization
studies on
cells swollen
under either
neutral or
alkaline
conditions
show that
deletion of
the MAR
interferes
with local
separation of
daughter
chromatids.
This
surprising
result
provides
direct genetic
evidence that
at least a
subset of MARs
performs an
important
biological
function,
possibly
related to
chromatid
cohesion and
separation.LD
Mesner, JL
Hamlin, PA
Dijkwel
Source: Proc Natl Acad Sci U S A, Vol. 100, No. 6. (18 March 2003), pp. 3281-3286. - Sister
Chromatid
Cohesion: A
Simple Concept
with a Complex
Reality.: Annual review
of cell and
developmental
biology (10
July 2008)In
eukaryotes,
the process of
sister
chromatid
cohesion holds
the two sister
chromatids
(the
replicated
chromosomes)
together from
DNA
replication to
the onset of
chromosome
segregation.
Cohesion is
mediated by
cohesin, a
four-subunit
SMC
(structural
maintenance of
chromosome)
complex.
Cohesin and
cohesion are
required for
proper
chromosome
segregation,
DNA repair,
and gene
expression. To
carry out
these
functions,
cohesion is
regulated by
elaborate
mechanisms
involving a
growing list
of cohesin
auxiliary
factors. These
factors
control the
timing and
position of
cohesin
binding to
chromatin,
activate
chromatin-boun
d cohesin to
become
cohesive, and
orchestrate
the orderly
dissolution of
cohesion. The
45-nm
ring-like
architecture
of soluble
cohesin is
compatible
with
dramatically
different
mechanisms for
both chromatin
binding and
cohesion
generation.
Solving the
mechanism of
cohesion and
its complex
regulation
presents
significant
challenges but
offers the
potential to
provide
important
insights into
higher-order
chromosome
organization
and chromosome
biology.
Expected final
online
publication
date for the
Annual Review
of Cell and
Developmental
Biology Volume
24 is October
06, 2008.
Please see
http://www.ann
ualreviews.org
/catalog/pubda
tes.aspx for
revised
estimates.Itay
Onn, Jill M
Heidinger-Paul
i, Vincent
Guacci, Elçin
Unal, Douglas
E Koshland
Source: Annual review of cell and developmental biology (10 July 2008)
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